The incidence of skeletal complications experienced by patients with metastatic prostate cancer is illustrated by the placebo group of a recent study of zoledronic acid in men with hormone-refractory prostate cancer
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چکیده
1522. 27.Saad F, Gleason D, Murray R, et al.,“Long-term reduction of bone pain with zoledronic acid in patients with advanced prostate cancer metastatic to bone”, [poster], Poster presented at:American Urological Association Annual Meeting;April 26 May 1, 2003; Chicago, Illinois,Abstract 1473. 28.Major P P, Cook R J, Chen B-L and Zheng M,“Zoledronic acid reduces the need for radiation to bone in patients with breast or prostate cancer metastatic to bone: a survival-adjusted cumulative incidence analysis”, [abstract], Proc.Am. Soc. Clin. Oncol. (2004), 23: p. 739,Abstract 8058. 29.Carroll P R,Altwein J, Brawley O, et al.,“Management of disseminated prostate cancer”, In: Denis L, Bartsch G, Khoury S, et al, (eds), Prostate Cancer: 3rd International Consultation on Prostate Cancer-Paris. Paris: Health Publications; (2003), pp. 251–284. 30.Smith M R, Eastham J, Gleason D M, Shasha D,Tchekmedyian S and Zinner N,“Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer”, J. Urol. (2003), 169: pp. 2,008–2,012. 31.Padalecki S S, Carreon M, Grubbs B, Cui Y and Guise T A, “Androgen deprivation enhances bone loss and prostate cancer metastases to bone: prevention by zoledronic acid”, Oncology (2003), 17 (suppl 3): p. 32.
منابع مشابه
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer.
In a placebo-controlled randomized clinical trial, zoledronic acid (4 mg via a 15-minute infusion every 3 weeks for 15 months) reduced the incidence of skeletal-related events (SREs) in men with hormone-refractory metastatic prostate cancer. Among 122 patients who completed a total of 24 months on study, fewer patients in the 4-mg zoledronic acid group than in the placebo group had at least one...
متن کاملRe: A Randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma.
The results of the well-conducted trial by Saad et al. (1) have prompted many to consider routine use of zoledronic acid to reduce the incidence of skeletal-related events in minimally symptomatic or asymptomatic men with hormone-refractory prostate cancer. This is a somewhat troublesome proposition, because all men in this situation are not at risk of a skeletal-related event. In the placebo a...
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Cancer constitutes a huge burden on societies in countries with any level of economic development. Prostate cancer is the first most diagnosed cancer of men in developed countries and the forth one in developing countries in terms of incidence rate. It is also the third incident cancer of men in Iran along with a prevalence of about 10,000 cases. Castration-resistant prostate cancer (CRPC) is a...
متن کاملA Systematic Review of Clinical Practice Guidelines for Castration-Resistant Prostate Cancer
Cancer constitutes a huge burden on societies in countries with any level of economic development. Prostate cancer is the first most diagnosed cancer of men in developed countries and the forth one in developing countries in terms of incidence rate. It is also the third incident cancer of men in Iran along with a prevalence of about 10,000 cases. Castration-resistant prostate cancer (CRPC) is a...
متن کاملNew Research Findings on Clinical Benefits of Bisphosphonates in Patients With Advanced Prostate Cancer
Objectives: Bone metastases develop in the majority of patients with advanced prostate cancer, and this fact puts these patients at high risk for potentially debilitating skeletal complications. Emerging therapies for the prevention of these complications are important for preserving patients’ quality of life. Methods: Existing and novel therapies were identified and researched through PubMed a...
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تاریخ انتشار 2005